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Dutasteride, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type 1 and type 2 5-alpha-reductase isoenzymes approved for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) who have an enlarged prostate. It has been demonstrated to be effective as monotherapy, or in combination with the alpha-adrenergic antagonist (α-blocker), tamsulosin, in several randomized, double-blind, placebo controlled trials and their open-label extensions. Treatment with Dutasteride is generally safe and well tolerated. Dutasteride has become established in the management of men with lower urinary tract symptoms (LUTS) and reduces the risk of acute urinary retention and surgery related to BPH. Dutasteride may also have a role as a chemopreventive agent in the future as emerging evidence demonstrates a reduced risk of prostate cancer with this agent.

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Dutasteride, Deetor, Duodart, Duprost, Dutagen, Dutas, Dutasterida, Dute, Veltride,

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Dutasteride comes as a capsule to take by mouth. It is usually taken once a day with or without food. Take dutasteride at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dutasteride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

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Antitumor activity of a folate-cleaving enzyme, carboxypeptidase G 1 . To assess the appearance of craving and withdrawal among four combination nicotine replacement treatments (NRTs). We experienced an extremely rare case of acute abdomen induced by ovarian congestion triggered by the fallopian tube accompanying a paratubal cyst coiling around the utero-ovarian ligament. In addition, no specific mechanism has been proposed for the actions of maternal infection on the developing brain that could account for schizophrenia risk. In a cross-sectional study we assessed the frequency of MSDs in 356 Iranian instrumentalists by standardized Nordic musculoskeletal questionnaire according to age group, type of instrument, duration of playing, and playing/sitting position.

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Patients who present with early stage non-small cell lung cancer and are poor candidates for lobar resection may be offered sublobar resection (commonly wedge) or stereotactic body radiotherapy (SBRT). A mechanism for the formation of cis-3,4-dihydroxymollugin acetonide from the reaction of mollugin with Oxone is proposed. In one subject, flow and tidal volume were monitored during quiet mouth breathing while NH3 and CO2 were sampled at the lips.

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The underlying mechanisms of how BMP4 mediates endothelial dysfunction and hypertension remain elusive. Some lymphoma clones appear to have affinity for the peripheral nerves or muscle tissues. The presence of a transplanted, fast-growing hepatoma (SS1-K) produces conspicuous ultrastructural changes in pituitary STH cells of C3H-S male mice. Recognition of the importance of vascular calcification in health is driving research into mechanisms that govern its development, progression, and regression. Attempts were made to parallel basic research findings with those derived from human pathology, hoping to gain further insight into the physiopathology of precocious puberty of cerebral origin.

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1,25-Dihydroxycalciferol and calcium therapy in osteoporosis with calcium malabsorption. FCMR-deficient B cells are sensitive to apoptosis induced by BCR ligation. Histologic examination of a biopsy from this lesion revealed a melanocytic neoplasm with moderate cellular anaplasia, frequent mitoses, and scant pigment production.

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The concepts of investment and counter-investment during the development of Freudian ideas Roles of circulating WNT-signaling proteins and WNT-inhibitors in human adiposity, insulin resistance, insulin secretion, and inflammation. Erythropoietin levels in the course of a patient with erythropoietin-producing renal cell carcinoma and transplantation of this tumor in nude mice. Therefore, these data suggest that MacMARCKS is an essential component in regulating cell adhesion.

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The combination of smoothelin and SMA represents a robust marker to discriminate MM from MP in the gastrointestinal tract. Complete relief of symptoms or marked improvement was noted in all but one patient. Activities of AP and beta-NAG were high in the two species with most of the activity located to the anterior and mid-parts of the worms. Vertical positioning of the scapular angle flap enables reconstruction of the facial contour, whereas its horizontal alignment and microvascular anastomosis makes a bony reconstruction of the hard palate possible. Thus, the purpose of this study was to compare the association between different indexes of muscle mass or strength with self-reported and measured functional performance to determine which index would be clinically relevant to detect individuals at risk of functional impairments.

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The tumour occurs typically in middle life and the aetiology is not known. The architecture should provide to the DS reliable trust information about systems and assist in the formulation of privacy policies. This hybrid polysaccharide-polypeptide microsphere may give promising application in drug delivery and tissue engineering. Incorporation of label from(1- 14 C)ethanol into the glutamate-glutamine pools of rat brain in vivo. The X-linked transcriptional repressor methyl CpG binding protein 2 (MeCP2), known for its role in the neurodevelopmental disorder Rett syndrome, is emerging as an important regulator of neuroplasticity in postmitotic neurons.

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Research aimed at novel treatments for HCV disease is gathering pace and very recent developments in cell-based assay systems can only hasten the discovery of improved therapies. The present study suggests that Phx-3 might be a potential anti-metastatic agent as well as an anticancer agent. Associations of structural and functional social support with diabetes prevalence in U.S. External encoders and accelerometers tracked microscope movements.

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This procedure is viewed as a relevant model for the study of human drug-taking behavior. Little is known about the rate of progression to chronic kidney disease (CKD) among hypertensive patients, particularly at the primary care level. In silico mutation evaluation predicted that the S168F mutation causes changes in the protein product which are damaging to its function. The effect of iron stores on iron absorption in the rat: the possible role of circulating ferritin.

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We aimed to investigate the potential existence of a correlation between any part of the IMRT process and clinical outcome. Hyperreflexivity as a condition of mental disorder: a clinical and historical perspective. A metabolomic approach based on an analytical platform could be able to separate, detect, characterize and quantify a wide range of metabolites and its metabolic pathways. To substantiate the synergism between CpG and Ag, we introduced a covalently linked conjugate between CpG and Ag and examined the efficacy on airway eosinophilia and Th2 cytokine production. Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines.

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Extractionless determination of 6-methoxy-2-naphthylacetic acid, a major metabolite of nabumetone, in human plasma by high-performance liquid chromatography. Urban residents reported significantly higher self-esteem and optimism than rural residents. The advantages of wearable green reflected photoplethysmography. A clinical method to determine the duration of various circulatory processes

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In the present study, we sought to determine the concentration of several trace elements (total and organic mercury, selenium, cadmium, lead, arsenic, copper, chromium, iron, manganese, molybdenum, vanadium and zinc) in muscle tissue of gilthead seabream (Sparus aurata), an edible finfish species that is widely cultured in the Mediterranean area. This article presents measurement methods used to determine the human exposure to electromagnetic fields radiated from operating base stations. The Y-shaped metallic stents were placed in the tracheobronchial tree with fluoroscopic guidance. The third patient developed hemiplegia on the tenth postoperative day, but recovered completely. We recently demonstrated that NTS1 receptors play a key role in the mediation of the analgesic effects of NT in long-lasting pain.

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In mechanomyography (MMG), crosstalk refers to the contamination of the signal from the muscle of interest by the signal from another muscle or muscle group that is in close proximity. Forty people with medial knee OA underwent 3-dimensional gait analysis to measure their peak knee adduction moment, an indicator of medial knee joint load.

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Although NADPH-d staining appears to be a poor indicator of the presence of NOS in this system, immunocytochemistry and in situ hybridization reveal that NOS is expressed in the axons of olfactory receptor neurons throughout development and in the perineurial sheath that covers the brain early in development. It offers extended possibilities and more electrodes combinations. Bone loss also correlated with the distance between adjacent teeth and implants. We resected her right inguinal lymph nodes and added 20 Gy photon radiations to both sides of the inguinal area. It embraces the social context of the individual and is inseparable from personal and social development.

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Immunocytochemical evidence suggesting that diamine oxidase catalyzes biosynthesis of gamma-aminobutyric acid in antropyloric gastrin cells. The amino acid sequence of PR fragment (NH2-terminal fragment) of bovine prothrombin. A sample of 92 Asian drug users (35 Chinese, 31 Filipino, 26 Vietnamese) who were not currently enrolled in drug treatment programs were recruited through targeted sampling methods and interviewed using a questionnaire with open-ended questions.

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This in vivo method of assessing the degree and composition of cellular infiltration in a contact allergic reaction after different periods of time throws new light on the influence of drugs on a cell-mediated immune response and also the variation in response with time. A channel for precision diagnosis and treatment in genetic epilepsy. The method is elucidated by the registration of the blood perfusion of a finger under repeated occlusion of the veins in the upper arm and with the velocity measurement of a liquid flow containing scattering particles.

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Correction of hypothyroidism requires high serum levels of dextrothyroxine than of levothyroxine. Numerous false positive results were encountered in the CA 19.9 assay in pulmonary diseases and in non-cancerous liver diseases, especially cirrhosis. Data acquisition, data manipulation and output handling of the results are performed by chaining 3 compiled BASIC programs. Following an in vivo case, we show with 2D simulations how assessment of tumor mobility can be achieved with shear strain estimation. Mesoporous silicas are currently widely studied carrier matrices in drug delivery applications.

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Addition of the solubility enhancers betaine and sorbitol or the co-enzyme pyridoxal phosphate showed no effect. The affinity profile of morphine-6-glucuronide as measured by binding experiments in membrane homogenates deviates from that of the parent compound. Here, foil actuators made out of 0.0508 mm, 0.0762 mm, and 0.127 mm thick AA1145 were used for launching AA2024-T3 sheets of thickness 0.508 mm toward a photonic Doppler velocimeter probe. Two of these 11 patients underwent mitral valve replacement, and myxomatous degeneration of the valves was noted on pathologic examination. This study investigates the heterogeneity in the use of linguistic context both between individual TD patients and within the individual patients as severity of thought disorder changes over time.

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Oxygen consumption of liver and kidney of Rana cancrivora in relation to environmental osmolality. Dopamine Augmented Rehabilitation in Stroke (DARS) is a multi-centre double-blind, randomised, placebo, controlled clinical trial of Co-careldopa in addition to routine NHS occupational therapy and physical therapy as part of early stroke rehabilitation. We investigate the recent Triplet Markov Fields and propose new models in this class designed for such data and in particular allowing very general noise models.

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A general formula is found that describes the measurement errors introduced by optical elements of the system. The observed changes in the number of copies of chromosomes 9 and 15 in the cells from the culture seem to indicate that the ratio of the genes localized in these chromosomes may be important for the growth in perpetuation of the cells.

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Remarkably, all participants were able to identify each of the three materials reliably, as well as the empty room. Specifically, we sought to identify acetabular component inclination and anteversion orientation, which simultaneously resulted in minimal wear while maximizing construct stability, for several permutations of femoral head diameter and femoral stem anteversion. Both total carbohydrate content and relative amount of sialic acid were higher in BSSL from the first lactation month as compared to BSSL from milk collected later in lactation. Establishment of interrater reliability for a nursing Extrapyramidal Side Effects (EPS) Assessment Scale. Highly permeable biocompatible dialysis membranes may postpone the development of AB-amyloidosis, but the relative contribution of enhanced flux or reduced inflammation by highly biocompatible membranes and sterile dialysis fluid remains unknown.

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This study aimed to investigate the long-term effects on systemic exposure of atorvastatin acid in the same group of patients. These pleiotropic effects are thought to include attenuation of the inflammatory response due to reduced prenylation of proteins in the inflammatory cascade. Disruption of taste aversion learning by pretreatment with diazepam and morphine. Retrospective case review of children completing dual growing rod treatment at our institutions.

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The influence of high intensity terahertz radiation on mammalian cell adhesion, proliferation and differentiation. This review presents an overview of the current literature on physical activity, specifically through active videogame systems (exergaming) and how these systems can help to increase physical activity levels.

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