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Dutasteride, a synthetic 4-azasteroid, is a selective and competitive inhibitor of both type 1 and type 2 5-alpha-reductase isoenzymes approved for the treatment of men with symptomatic benign prostatic hyperplasia (BPH) who have an enlarged prostate. It has been demonstrated to be effective as monotherapy, or in combination with the alpha-adrenergic antagonist (α-blocker), tamsulosin, in several randomized, double-blind, placebo controlled trials and their open-label extensions. Treatment with Dutasteride is generally safe and well tolerated. Dutasteride has become established in the management of men with lower urinary tract symptoms (LUTS) and reduces the risk of acute urinary retention and surgery related to BPH. Dutasteride may also have a role as a chemopreventive agent in the future as emerging evidence demonstrates a reduced risk of prostate cancer with this agent.

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Dutasteride comes as a capsule to take by mouth. It is usually taken once a day with or without food. Take dutasteride at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take dutasteride exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

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Antitumor activity of a folate-cleaving enzyme, carboxypeptidase G 1 . To assess the appearance of craving and withdrawal among four combination nicotine replacement treatments (NRTs). We experienced an extremely rare case of acute abdomen induced by ovarian congestion triggered by the fallopian tube accompanying a paratubal cyst coiling around the utero-ovarian ligament. In addition, no specific mechanism has been proposed for the actions of maternal infection on the developing brain that could account for schizophrenia risk. In a cross-sectional study we assessed the frequency of MSDs in 356 Iranian instrumentalists by standardized Nordic musculoskeletal questionnaire according to age group, type of instrument, duration of playing, and playing/sitting position.

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Patients who present with early stage non-small cell lung cancer and are poor candidates for lobar resection may be offered sublobar resection (commonly wedge) or stereotactic body radiotherapy (SBRT). A mechanism for the formation of cis-3,4-dihydroxymollugin acetonide from the reaction of mollugin with Oxone is proposed. In one subject, flow and tidal volume were monitored during quiet mouth breathing while NH3 and CO2 were sampled at the lips.

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The underlying mechanisms of how BMP4 mediates endothelial dysfunction and hypertension remain elusive. Some lymphoma clones appear to have affinity for the peripheral nerves or muscle tissues. The presence of a transplanted, fast-growing hepatoma (SS1-K) produces conspicuous ultrastructural changes in pituitary STH cells of C3H-S male mice. Recognition of the importance of vascular calcification in health is driving research into mechanisms that govern its development, progression, and regression. Attempts were made to parallel basic research findings with those derived from human pathology, hoping to gain further insight into the physiopathology of precocious puberty of cerebral origin.

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Research aimed at novel treatments for HCV disease is gathering pace and very recent developments in cell-based assay systems can only hasten the discovery of improved therapies. The present study suggests that Phx-3 might be a potential anti-metastatic agent as well as an anticancer agent. Associations of structural and functional social support with diabetes prevalence in U.S. External encoders and accelerometers tracked microscope movements.

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Extractionless determination of 6-methoxy-2-naphthylacetic acid, a major metabolite of nabumetone, in human plasma by high-performance liquid chromatography. Urban residents reported significantly higher self-esteem and optimism than rural residents. The advantages of wearable green reflected photoplethysmography. A clinical method to determine the duration of various circulatory processes

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To comprehensively evaluate the risk factors of stroke identified in prospective Western and Asian cohort studies. This paper reviews the evidence that relates malocclusion to psychological health and quality of life and explores whether this evidence supports the most commonly used aesthetic Orthodontic Treatment Need Indices sumatriptan dosage limits (OTNI). Is malignant nodule topography an additional risk factor for metastatic disease in low-risk differentiated thyroid cancer?

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