FREE
SHIPPING!

on all orders above $300.00

FREE Pills!

VIAGRA PILLS

for free with every order

OUR DRUG PRICES are

70%

Less than in your
local pharmacy

Search by letter:

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Enter coupon: (if you have one)

Amantan (Amantadine)
+ BONUS
 
Amantadine

The pore maintains its integrity to the N terminal side of the membrane, and at the same time, a cavity is generated that appears adequate for binding Amantan. In a double treatment of isoquercetin and Amantan, synergistic effects were observed on the reduction of viral replication in vitro.

Other names for this medication:
Amantadine, Symmetrel, Aman, Amantadina, Amantan, Amixx, Antadine, Lysovir, Mantadan, Mantadix, Protexin, Symadine, Tregor, Viregyt, Virosol,

Similar Products:
Alvastin, Trichex, Bromodel, Flubiotic, Androfin, Pexeva, Viaclav, Dicloduo, Seropram, Sortiva, Strattera, Lorazepam, Torvalipin, Tramacip, Valax, Lacine, Tryptizol, Argofan, Envarsus, Wiatrim, Braxan, Normodyne, Zocor, Sylatron, Omicap, Tropargal, Dicloflam, Metronidazole, Flagyl, Antidep, Antara, Volfenac, Betamox, Ambiz, Coverene, Innozide, Hypace,

Amantan is an antiviral medicine. It is used to prevent or treat certain influenza (flu) infections (type A). It may be given alone or together with flu shots. Amantan will not work for colds, other types of flu, or other virus infections.

Amantan is also an antidyskinetic medicine. It is used to treat Parkinson's disease (sometimes called "paralysis agitans" or "shaking palsy") and its symptoms, including dyskinesia (sudden uncontrolled movements). It may be given alone or in combination with other medicines (eg, levodopa) for Parkinson's disease. By improving muscle control and reducing stiffness, this medicine allows more normal movements of the body as the disease symptoms are reduced. Amantan is also used to treat stiffness and shakiness caused by certain medicines that are used to treat nervous, mental, and emotional conditions.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet, Extended Release
  • Capsule, Liquid Filled
  • Tablet
  • Solution
  • Syrup
  • Capsule
  • Capsule, Extended Release

amantan multiple sclerosis symptoms

These substitutes are fermented by few oral bacteria and no negative adaptation of the oral flora has been observed. TBCA was performed from volumes defined by tractography with gradually changed FA thresholds. The triglyceride/high-density lipoprotein cholesterol ratio fails to predict insulin resistance in African-American women: an analysis of Jackson Heart Study. Possible misunderstanding between the patient and nursing personnel Problems of guaranty in sales conditions of swine breeding associations in the Federal Republic of Germany

amantan multiple sclerosis symptoms

Serum spleen tyrosine kinase and vascular endothelial growth factor-C levels predict lymph node metastasis of oesophageal squamous cell carcinoma. The effect of gossypol, praziquantel and artemether on recombinant lactate dehydrogenase from Schistosoma japonicum The results showed that the contents of Pb and Mn in soil planting navel orange were significantly higher than those in the control soil, but the contents of Cd, Cu and Zn showed no significant difference.

amantan multiple sclerosis symptoms

However, only tonsillectomy in the presence of tonsillar hypertrophy and maxillomandibular advancement are recommended in carefully selected cases. Cellular damage was measured by either MTT assay or release into the medium of lactate dehydrogenase (LDH). As initially demonstrated with murine cytomegalovirus (MCMV), plasmacytoid dendritic cells (pDCs) are the major source of IFN-alpha/beta in response to a variety of viruses in vivo. On comparison with the respective monotherapy, the renal tolerance for cephalothin-aminoglycoside combinations was reduced. For prevention and amelioration of insulin resistance in Asian Indian adolescents and young adults, it is prudent to have normal BMI and low intake of omega-6 PUFAs.

amantan multiple sclerosis symptoms

Dithionite-induced changes in the spectra of free and enzyme-bound pyridoxal phosphate. Hair cortisol, stress exposure, and mental health in humans: a systematic review. The concentrations of cephalothin were determined during the first (early) and second (late) hours of the operation.

amantan multiple sclerosis symptoms

The cognitive profile of schizophrenic patients with and without comorbid substance abuse disorder was compared with that of patients suffering from major depression or alcoholism and healthy participants. PAX8 expression in uterine adenocarcinomas and mesonephric proliferations. This multimodal characterization may be useful in selecting possible tumor subtypes that would benefit from antiangiogenic therapy. A variety of protein and peptide molecules with various amino acid sequences form these highly stable and well-organized assemblies under diverse conditions.

amantan multiple sclerosis symptoms

The visual acuity should decline with axial length extension, diopter deepening and pathological deterioration of fundus. In order to reduce the time required for the sample exchange, the single tongs of the SAM system were modified and a double-tongs system that can hold two cryo-pins at the same time was developed. A high nuclease activity in the lymphocyte nuclei provides for a deeper endonucleolysis of the lymphocyte chromatin as compared to that in the liver nuclei. We have gradually learnt that heme oxygenase-derived carbon monoxide (CO) serves as a ubiquitous signaling mediator which could be exploited for therapeutic purposes.

amantan multiple sclerosis symptoms

It is suggested that although the interaction of the saponin with sterols is much more specific than with other membranal components, the lysis of plasmodia of P. We found an attenuation of the insulin response as indicated by lower glucose uptake and decreased phosphorylation of Akt upon insulin stimulation of adipocytes with mitochondrial dysfunction. Regional nodal metastasis in nasopharyngeal carcinoma plays an important role in the definition of radiotherapy area and clinical stage.

amantan multiple sclerosis symptoms

Various reports implicate PML and PML nuclear bodies (NBs) in an intrinsic antiviral response targeting diverse cytoplasmic replicating RNA viruses. To this end, a novel 1q25.3 MLPA probe set was designed and a commercially available 1q25.3/1p35.2 dual color FISH probe set was used.

amantan multiple sclerosis symptoms

Debye process in Ibuprofen glass-forming liquid: insights from molecular dynamics simulation. The combination of these variables is a useful and easy tool for determining appropriate therapy. Alpha- and gamma-motoneurons in the adult human spinal cord and somatic cranial nerve nuclei: the significance of dendroachitectonics studied by the Golgi method. After long-term Cd exposure, we found differences between GSL patterns in leaves and root. Our results suggest that TTV and SEN-V might play a role in the development of liver disease in patients with immunodeficiency diseases.

amantan multiple sclerosis symptoms

Gas-liquid chromatography of hydroxamic acids in biological samples. In addition, various biological characteristics, such as total length (TL), body weight (BW) and age, and number of downstream migration (NDM) were correlated.

amantan multiple sclerosis symptoms

Compared with normal skin, vitiligo lesional skin contained 17 genes (mostly melanocyte-specific genes) whose expression was decreased or absent. NLPHL is a rare disease, thus these are limited experiences with its diagnosis and treatment. We reported the 2 cases of hepatitis B reactivation receiving chemotherapy for solid cancer in terms of patterns and characteristics of reactivation. Nodular enhancement of the internal auditory canal was observed in three patients. This might increase the duration of exposure of drug to and, hence, the extent of metabolism by enterocyte CYP3A4.

amantan multiple sclerosis symptoms

One anterior labral tear detected by MRI could not be verified by arthroscopy. The metabolic syndrome defined by modified International Diabetes Federation criteria and mortality: a 9-year follow-up of the aged in Finland.

amantan multiple sclerosis symptoms

Accumulation of mature core at these times coincided with its localization to lipid droplets and a rise in titer of infectious HCV. Effect of spectacular reflection on out-of-plane ultrasonographic images reconstructed from three-dimensional data sets. The aim of this study was to determine the accuracy of specimen-specific finite element models of untreated and cement-augmented vertebrae by direct comparison with experimental results. Three different surgical techniques were compared to each other.

amantan multiple sclerosis symptoms

Investigating the EPI funds input, staff arrangement, normal standardized management and vaccine coverage rate before and after Yellow Card Warning System implementation in all 88 counties of Guizhou Province, and analyzing the data with descriptive epidemiology. J.) performed 119 consecutive total knee arthroplasties in eighty-six patients with LCS rotating-platform femoral and tibial components and a Townley all-polyethylene dome patellar component. All of them denied the history of contact with a known case of leprosy. Social epidemiology: how socioeconomic risk factors become health realities.

amantan multiple sclerosis symptoms

Optic disc size and other parameters from optical coherence tomography in Vietnamese-Americans. The response of normal and drug-resistant strains of Plasmodium berghei. Using radioautographic technique actinomycin D at a concentration of 0.08 mug/ml was shown to inhibit selectively ribosomal RNA (rRNA) synthesis in monolayer cultures of Chinese hamster cells. One advice to the decision of graft size for ascending and total arch graft replacement (in a case of differential diameters in ascending aorta and descending aorta)

amantadine mechanism action influenza incubation

  • amantadine package insert pdf in excel
  • amantadine influenza treatment 2016
  • what is amantadine 100 mg used for
  • amantadine for fatigue in ms and side effects
  • amantadine hydrochloride usp monograph dandrift
  • what is amantadine drug used for
  • amantadine dosage for concussions
  • amantadine hcl tablets for digestion
  • amantadine hcl msds liquid
  • amantadine 100 mg capsule pictures
  • amantadine drug manufacturer of prevacid
  • amantadine dose and duration
  • can amantadine capsules be opened mind
  • amantadine dosage forms of vicodin
  • gintoki and katsura vs amantadine
  • meythaler amantadine dosage
  • amantadine action in parkinson's disease
  • amantadine side effects drug
  • respiratory virus infection agents amantadine
  • amantadine influenza treatment
  • m2 amantadine medication
  • amantadine influenza treatment outside of 48
  • amantadine dosage
  • main site of action of amantadine 100
  • amantadine drug action movies
  • amantadine hcl capsules and rosacea
  • amantadine mechanism of action animation
  • amantadine concussion headache treatment
  • amantadine parkinson's tremor medications
  • amantadine mechanism of action animation films
  • amantadine costco auto
  • amantadine costco
  • amantadine dosage forms of medical cannabis
  • amantadine uses parkinson's and depression
  • amantadine costco black
  • amantadine mechanism of action parkinson's treatment
  • novel use of amantadine to treat hiccups while sleeping
  • amantadine for ms reviews
  • amantadine hydrochloride capsules usp monographs
  • tardive dyskinesia treatment amantadine adhd
  • amantadine 100mg capsules p.o. b.i.d
  • amantadine drug test
  • amantadine cost ukraine
  • amantadine hydrochloride nursing implications
  • amantadine post tbi alcohol
  • amantadine mechanism of action anti virals
  • amantadine hcl bcs classic baseball
  • amantadine for ms reviews on garcinia
  • amantan multiple sclerosis symptoms
  • amantadine hydrochloride nursing implications definition
  • lysosomotropic amantadine hydrochloride
  • amantadine mechanism action influenza incubation
  • amantadine mechanism of action parkinson's and dementia
  • amantadine drug group discussion
  • amantadine hcl brand name
  • amantadine for ms fatigue reviews on spirit
  • amantadine side effects hallucinations when waking
  • amantadine parkinson's tremors alcohol
  • side effects of amantadine hcl characteristics
  • amantadine for ms-related fatigue syndrome
  • amantadine uses parkinson's stages of progression
  • amantadine brand name in pakistan politicannews
  • livedo reticularis caused by amantadine dosage
  • amantadine drug study scribd login
  • difference between amantadine and memantine hcl
  • amantadine drug study scribd books
  • amantadine drug uses
  • amantadine dosage for adults
  • amantadine and rimantadine influenza a symptoms
  • amantadine hcl tablets for kids
  • mechanism of action of amantadine hcl side
  • amantadine price in pakistan a300f
  • amantadine parkinson's tremors treatment
  • amantadine 100 mg concussions
  • amantadine side effects hallucinations while sleeping
  • amantadine vs tamiflu
  • amantadine price in pakistan lumia
  • is amantadine an antibiotic
  • amantadine tbi dosing
  • amantadine for ms fatigue reviews on wen
  • amantadine influenza treatment pediatrics
  • amantadine hydrochloride capsules 100mg clomid
  • amantadine hydrochloride capsules usp monograph modernization
  • amantadine dosage and administration
  • amantadine hydrochloride capsules usps
  • amantadine medication for mono
  • side effects amantadine in dogs
  • amantadine for tbi treatment phoenix

amantadine for tbi treatment phoenix

The Chronic Care Model provides a useful framework for understanding the impact of chronic disease management interventions and highlights the gaps in evidence. The automatic behavior syndrome is characterized by continuation of mechanical activity and complete amnesia. Microembolization at reperfusion augments infarct size, but postconditioning in the presence of microembolization still reduces infarct size and attenuates infarct expansion. As an important therapeutic consideration, we describe psychologically detrimental effects of delayed estrogen treatment with an older Turner syndrome patient.

amantadine parkinson's tremors alcohol

After direct blotting, the released mRNA was quantified by hybridization with a labeled plasmid containing a beta-globin DNA restriction fragment. It appears that the predominant mechanism of urethral resistance is alpha-adrenergic activity in smooth muscle.

amantadine drug test

Three-dimensional scar maps can be created from the imaging datasets, which are uploaded into clinical mapping systems, and can facilitate substrate-guided ablation procedures. Six of the epileptics were treated orally with 0.5 microgram of 1,25-dihydroxycholecalciferol (1,25-DHCC) per day and six with 10 microgram of 25-hydroxycholecalciferol (25-HCC) per day for 10 days. The cognate chromosomal gene consists of 2,071 bp and comprises 11 introns with a size range of 78-202 bp. A heparinized catheter was used for the regional infusion of 5-fluorouracil in seven patients with liver metastases.

lysosomotropic amantadine hydrochloride

Ataxic postural reactions were observed consistently during lateral weight shifting phases toward the stance limb. Whereas conditioning of the 3-day-old chicks under high ambient temperatures for 24h diminished the number of newborn cells in anterior hypothalamic structures 1 week after the treatment, mild heat stress did not influence the amount of new cells. The most psychologically distressed carers increased their emotion-focused coping and did not decrease their dysfunctional coping, while others benefited but not through this mechanism. Data included preoperative and postoperative hemoglobin, absolute reticulocyte count, splenic size, operative time, complications, and length of stay. The resulting atlas can be used to plan experimental approaches that require the accurate identification of a target spinal cord segment.

amantadine parkinson's tremors alcohol

The effects of electrical stimulation on the motor and sensory system during stereotaxic operations. This study was a cross-sectional retrospective analysis of National Ambulatory Medical Care Survey physician visit survey data from 1998 through 2004. To test the hypothesis that the motivational effects of neonatal undernutrition might conceal the detrimental effects on learning, we tested previously undernourished and normally nourished Sprague-Dawley rats on learning of a novel maze pattern under either latent learning (nonappetitive) or food-motivated conditions.

amantadine mechanism action influenza incubation

The first analysis was conducted to obtain a statistical model that classified 105 female healthy subjects and 38 female schizophrenia patients. In the subset of patients with baseline advanced liver fibrosis, treatment provides clinical benefit despite lack of sustained virological response. In spite of large doses of phenoperidine, diazepam and a number of other analgesics and sedatives, all patients were restless, agitated and coordinated poorly with the respirator.

side effects of amantadine hcl characteristics

This unit presents protocols for examining the functional effects elicited by nonspecific acid or alkaline phosphatases that dephosphorylate many phosphoproteins in vitro. We analyzed preoperative weight loss as a predictor of postoperative success in patients after bariatric surgery. Pelvis and torso kinematics and their relationship to shoulder kinematics in high-school baseball pitchers. Coronary flow velocity reserve (CFVR) is a frequently used parameter for evaluating the physiological significance of epicardial stenosis and microvascular function.

amantadine and rimantadine influenza a symptoms

We monitored withdrawal symptoms, pain intensity, type, and intensity of adverse events. Patients with large inguinoscrotal hernias and sacs extending deep into the scrotum can benefit from reduction and fixation of the distal sac high and laterally to the posterior inguinal wall. Pitfall of the blood HCG value in the suprasellar region germinoma

amantadine hcl msds liquid

Placental localization with radioactive isotope indium ( 113 m In) in the management of ante-partum hemorrhage. The BoneScalpel is a safe and technically feasible device for performing osteoplastic laminoplasty. Previously, we reported that our MNP formulation can provide prolonged contrast for tumor magnetic resonance imaging and can be loaded with hydrophobic anticancer agents for sustained drug delivery. These findings collectively demonstrate for the first time that PDGF-D induces COX-2 by transcriptional upregulation in RMCs and the induction is largely related to PI3K/PKB and PKCs activities.

amantadine cost ukraine

The plasma is incubated with an antiserum to E217beta-BSA and the gamma-globulin fraction precipitated with ammonium sulphate. Previous studies have suggested that penbutolol may increase the glomerular filtration rate. Combined scanning tunneling microscopy experiments and molecular dynamics modeling of a supramolecular rotor with respective rotation rates matching with 0.2 kcal mol(-1) (9 meV) precision, identify key steps in collective rotation events and reconfigurations.

respiratory virus infection agents amantadine

Over the past two decades, great strides have been made in the field of tissue engineering. A study of single-dose digoxin kinetics was performed in 6 young and 7 elderly patients. NEPFOS and PFOS were potent stimulators of proximal tubule basal oxygen consumption (QO(2)), with initial effects exhibited at 5-10 mum and maximal effects at 50-200 mum. Note on the distribution of iodine-123-labeled indocyanine green in the eye. Cancer incidence trends use by health officials in order to program evaluations and development of cancer control strategies.

mechanism of action of amantadine hcl side

The findings also demonstrated that the risk of requiring secondary management increased with the severity of the cleft. Recently, approaches have been developed to analyze multi-parametric HCS data more completely and, when used in conjunction with RNA interference, target-based biochemistry and structural analysis, these approaches have begun to unlock the potential of this screening format in aiding drug discovery.

mechanism of action of amantadine hcl side

Role of fungi in the pathophysiology of chronic rhinosinusitis: an update. Based on this designer signaling cascade, it was possible to use guanabenz to dose-dependently control expression of GLP-1-Fc(mIgG)-Leptin, a bifunctional therapeutic peptide hormone that combines the glucagon-like peptide 1 (GLP-1) and leptin via an IgG-Fc linker. Extracellular fluid and total potassium content in obesity patients It is applicable to the initial placement of the catheter, to any necessary alterations in its position, and to its eventual replacement with a central venous cannula.

amantadine mechanism of action parkinson's and dementia

The long-axis diameter (LAD) and short-axis diameter (SAD) of all visualized lymph nodes were measured with transverse MDCT images. We propose an entropic driving mechanism for the experimentally observed destabilization of dsDNA that is rooted in the higher affinity of the DNA bases for trehalose than for water, which promotes base exposure and DNA melting. In the midbrain, there was a direct relationship between the decrease in met-enkephalin levels and the increase in HVA levels. What responsibility does medicine assume, as an institution and a community of agents, in this anthropological choice? Regulation of the JNK signaling pathway by dual leucine zipper kinase DLK.

meythaler amantadine dosage

The other two cordyceps-like families, Cordycipitaceae and Clavicipitaceae, will be revised taxonomically elsewhere. The goal of cognitive neuroscience is to identify the mapping between brain function and mental processing. A retrospective national study in a proportionate random sample of 25 medico-legal laboratories was carried out to identify all homicides in 1999 of women over the age of 13 years. The PCQ-infertility can identify shortcomings on patient-centredness and can be adopted for quality improvement. In both parasite and host tissue RNA-label was removed after RNase treatment.

amantadine for ms reviews on garcinia

The catechism effect: child testimonies during a 17th-century witch panic as related to educational achievement. The inclusion criteria were a minimum follow-up of 12 months, indications for lumbar dynamic stabilization, and assessment of clinical outcomes and adverse events.

amantadine hydrochloride nursing implications definition

Concentration of p185(neu) protein was determined by using enzyme immunoassay and evaluated by using several variables. Cases included 6,943 (516 women, 6,427 men) active duty Soldiers that were retrospectively analyzed from a pre- and post-deployment screening database at a large Army installation. Here, we demonstrate that sedDNAs are localized to the nucleus in two biochemically distinct forms, which include chromatin-associated, transcription factor II H-bound complexes and more readily solubilized, RPA-bound complexes. The results revealed no pronounced changes in identity, net activity or concentration of the gelatinases or changes in concentrations of TIMP-1 and TIMP-2 in BAL fluid before and after acute exposure to tobacco smoke.

Testimonials
Best
 Show Hide 
lysosomotropic amantadine hydrochloride 2011-07-10

HLA-A and -B antigen frequencies were compared with data reported for European Caucasoids and various Arab populations. The external phenotype was that of a female, but internally there was one ovotestis, containing both ovarian follicles and testicular tubular elements, and a contralateral ovary. Inhibiting RA signaling in utero resulted in a significantly higher amount of precursor-LECs at the expense of mature LECs and turfa gel nail caused nuchal edema.

m2 amantadine medication 2018-09-24

The development of colorectal cancer is influenced by exogenous factors, such as dietary constituents and drugs. The findings of behaviorally oriented research regarding the importance of cognitive-motivational variables in hypnosis are examined and some clinical and theoretical implications are explored. We sought to evaluate postoperative bleeding complications aldactazide 50 mg pap in patients who underwent Mohs micrographic surgery while using multiple agents perioperatively compared with patients using a single agent or none at all.

tardive dyskinesia treatment amantadine adhd 2013-02-27

The interrelationship between medicine breastfeeding cold eeze the Ebbinghaus and Delboeuf illusions. Persistent pulmonary hypertension is a major cause of morbidity and mortality in the term and near-term infant.

amantadine mechanism of action anti virals 2015-10-04

This study investigates the roles of glucose and the catabolite repression system in Serratia marcescens biofilm formation. Study results were evaluated and five methodological criteria were assessed: (1) randomization of discordant test results, (2) use of a fixed management protocol, (3) description of interventions in relation to the test result, (4) evaluation of a learning curve, and (5) sample size calculation in agreement with the prevalence of the test results. A rare complication of nizoral dandruff shampoo target market diverticulosis of the colon is giant colonic diverticulum, an entity first described by Bonvin in 1946. The heat shock protein 90 (Hsp90) family of heat shock proteins is an abundantly expressed and highly conserved family of ATP-dependent molecular chaperones. Case of hysteric syndrome with a variety of syndromes associated with mental anorexia and lientery

amantadine hydrochloride capsules usp monographs 2015-12-08

Nettleship, Pearson and Bateson: the biometric-Mendelian debate in a medical context. Effect of a Calotropis procera-based feed on mebendazole dosage for tapeworm in cats embryonic and neonatal mortality in laboratory mice

lysosomotropic amantadine hydrochloride 2018-07-21

Though 65 cases of IPT have been reported in the literature (1839-1996), in the present case there were over 15 germ derivatives, the largest number reported to date. While variables such as host factors and treatment strategies determine the outcome of infection, our in vitro studies evaluated the virulence of the isolates associated with this outbreak. Published reports identified through a search of fenofibrate manufacturer coupon PubMed database (from 1964 to November 2011) were reviewed to record clinical, serological and pathologic findings. Matrix metalloproteinases (MMPs) play important roles in cancer invasion and metastasis.

amantadine tbi dosing 2013-02-14

The complete profile of rhamnolipid congeners produced during a 2 week cultivation period was monitored. Frequent and possibly inappropriate use of combination therapy with an oral anticoagulant and antiplatelet agents in patients with atrial fibrillation in Europe. acic 800 mg hexal ag Findings suggest family history of drug abuse and a history of criminal behavior can increase likelihood of drug diversion. The palladium-catalyzed Suzuki-Miyaura reaction of aryl, heteroaryl, and alkenyl halides with arylboronic acids and sodium tetraarylborates was performed with the catalytic membrane-installed microchannel devices to give quantitative yields of biaryls, heterobiaryls, and aryl alkenes within 5 s of residence time in the defined channel region.

amantadine costco 2015-12-08

Among the omeprazole generico ou similar artists web tools used, auditors rated MS Visual Oblique as the most valuable. Relative risk of hypoglycaemia and related diagnoses were two- to sevenfold higher in the post-gastric bypass population, but absolute risk was small. Partial nephrectomy (PN) is a preferred treatment for cT1 renal masses, whereas thermal ablation represents an alternative nephron-sparing option, albeit with higher reported rates of recurrence.

amantadine costco 2019-04-17

Besides an indirect carotid-cavernous fistula on the left side, a right-sided persistent trigeminal artery terminating as the dominant hemispheric trunk of the posteroinferior cerebellar artery was incidentally noted. Appropriate patient selection and a better understanding of the technique are paramount to successful valacyclovir hcl 1 gram tablet shingles vaccine bone regeneration with alveolar distraction osteogenesis.