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Novacan (Fluconazole)

Novacan is a synthetic compound known as a bis-triazole. It was first used in patients 1994/95 and licensed for use in 1990. It went off patent in 2003. It works by inhibiting the production of ergosterol, a central chemical in the cell walls of fungi. The drug is available as a capsule, oral suspension and intravenous infusion. A typical dose for oral thrush is 100mg per day. The typical dose for vaginal thrush is a 150mg per day. For the prevention of fungal infections in leukaemia, doses from 50-400mg per day have been used and studied. Most authorities recommend between 100 and 400mg. For the treatment of candidemia and other serious Candida infections a minimum dose of 400mg per day (after a loading dose of 800mg) is recommended with increased doses in patients on haemofiltration and/or rifampicin (see below). Some authors have suggested that 800mg is superior for candidaemia, but the data is not compelling. For the treatment of cryptococcal meningitis after amphotericin B, a minimum of 400mg per day initially is used until the patient is stable and then typically 200mg per day. Much larger doses e.g. 800-1200mg per day should be used as an alternative primary regimen (preferably with flucytosine) or for patients failing therapy. Larger doses such as 800-1200mg per day have been used for coccidioidal meningitis. Almost all other treatments have been for 100-400mg per day. Reduced doses may be appropriate in severe renal dysfunction.

Other names for this medication:
Fluconazole, Diflucan, Afumix, Afungil, Batacan, Candidin, Diflazon, Difluzol, Difluzole, Dizole, Dofil, Duracan, Efac, Elazor, Exomax, Farzul, Fluc, Flucomed, Flucon, Fluconapen, Fluconazol, Flusenil, Flutec, Fluvin, Fluzol, Fluzole, Fluzone, Forcan, Govazol, Honguil, Ibarin, Kifluzol, Lavisa, Logican, Lucon, Medoflucon, Novacan, Omastin, Ozole, Ponaris, Rifagen, Sacona, Stabilanol, Syscan, Ticamet, Trican, Triflucan, Trizol, Uzol, Varmec, Zemyc, Zoldicam, Zolen, Zoloder, Zucon,

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Parkan, Onic, Normatens, Antiox, Norfloxacin, Pylorid, Omifin, Pripsen, Prazidec, Efferven, Prysma, Zolax, Valtan, Agulan, Procap, Clavinex, Lefloxin, Bendex, Fenixa, Nexx, Myclav, Actine, Oxyteracin, Prohair, Pulna, Pediamox, Dolmax, Moxiclav, Warafin,

Novacan injection is used to treat serious fungal or yeast infections, such as vaginal candidiasis, oropharyngeal candidiasis (thrush, oral thrush), esophageal candidiasis (candida esophagitis), other candida infections (including urinary tract infections, peritonitis [inflammation of the lining of the abdomen or stomach], and infections that may occur in different parts of the body), or fungal (cryptococcal) meningitis. This medicine works by killing the fungus or yeast, or preventing its growth.

Novacan injection is also used to prevent candidiasis in patients having bone marrow transplants, who receive cancer or radiation treatment.

This medicine is to be given only by or under the direct supervision of a doctor.

This product is available in the following dosage forms:

  • Solution

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By employing the radiocarbon dates as internal calibrations, we co-estimate the bovine phylogeny and divergence times in a relaxed-clock framework. We have found increased expression of MMPs in clinical samples of CSK compared to normal corneas. In contrast, ectopic TSP-1 expression in SiHa cells has little effect on the invasive ability of the NIH3T3 cells.

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Effects of glycine and glyoxylate on cerebral glucose oxidation in vitro. This study investigates translocation in peritonitis and ischemia/reperfusion by inoculating different bacterial species into the small intestine.

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Lower limits of SBP are less defined in current guidelines optimizing HF. Here we describe the cellular effects of the pharmacological inhibition of the checkpoint kinase Chk1 by the novel inhibitor V158411 in triple-negative breast cancer and ovarian cancer. Observations on fallopian tube implantation in the treatment of conjugal sterility

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In analogy to the acid reflux DGER increases with the gravity of oesophageal lesions. Perception of CHD risk information is affected by the presentation format. Hyponatremia and seizures presenting in the first two years of life. High expression of ErbB2 contributes to cholangiocarcinoma cell invasion and proliferation through AKT/p70S6K.

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MEN1 is associated to some cutaneous lesions and could be useful for detecting MEN1 carriers in an affected family. Neighbor Joining (NJ), FastME, and other distance-based programs including BIONJ, WEIGHBOR, and (to some extent) FITCH, are fast methods to build phylogenetic trees. En face maximum projection was used to obtain 2D disc angiograms, from which the average decorrelation values (flow index) and the percentage area occupied by vessels (vessel density) were computed from the optic disc and a selected region within it.

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Proceedings: Cryophotometry, a method of analysis of a momentary functional state of an organ. Recent reports have indicated that the viral load within the tumor, along with other factors, may be correlated to the patient survival. The partial or complete occlusion and the respect to the near vessels were evaluated.

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In affected tissues, glycogen storage was higher than in wild-type mice, even in the central nervous system which has never been tested in GSDIII patients. Our simulations demonstrated that for moderate to good IRA, excellent AGT could nonetheless be obtained.

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Nonetheless, major challenges in tailoring patient-specific treatment regimens involve predicting the most effective inhibitors and monitoring for acquisition of resistance. Mice engineered for an obligatory Mdm4 exon skipping express higher levels of the Mdm4-S isoform but exhibit increased p53 activity. Fosfomycin sodium inhibited activities on the isolated smooth muscles, elevated body temperature, and increased permeability of skin vessels.

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Optical multiscale morphological processor using a complex-valued kernel. It is apparent that a greater awareness of the critical role of pathologists in determining eligibility for active surveillance is needed.

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Versican expression is associated with tumor-infiltrating CD8-positive T cells and infiltration depth in cervical cancer. Other areas in the NTS and PBN may receive gustatory inputs since more dominant c-FLI was detected by intraoral rather than intragastric infusions of the stimuli. Metal ion-carbonyl oxygen recognition in complexes of acetyl phosphate. A further endoscopic examination was performed at the end of treatment: no patient showed evidence of gastric or duodenal peptic ulcers or erosions. This case illustrates the clinicopathologic features of a luteinized follicle cyst of pregnancy with special emphasis on the cytologic characteristics.

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Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder. Interfacial chemistry of poly(methyl methacrylate) arising from exposure to vacuum-ultraviolet light and atomic oxygen. Our findings demonstrate that all of the potential Drosophila cathepsin L-like proteins contain at least one cathepsin propeptide inhibitor domain.

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Enterohemorrhagic Escherichia coli (EHEC) strains of serogroup O118 display three distinctive clonal groups of EHEC pathogens. The classical methods to detect DNA methylation require labor-intensive and time-consuming steps. They were either previously untreated or relapsed after one or more previous treatments with systemic therapy. Due to its small size and complex tissue architecture, the mammalian inner ear provides a particular challenge to the development of whole organ culture. In combination with histological stain, FTIR and infrared micro-spectroscopy, the characteristics of OMI were analyzed morphologically and molecularly.

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Chemokine (C-C motif) ligand-3, chemokine (C-C motif) ligand-5 and chemokine (C-X-C motif) ligand-1 were the molecules mostly related to Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus faecalis inhibition. Developmental toxicity of 2-chlorodibenzofuran in cultured post-implantation rat embryos.

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This was not expected from the study of the individual linker alone, indicating the need to study the system as a whole as opposed to the isolated components. Serum M-CSF was proven to be useful as a tumor marker for detecting squamous cell carcinoma arising in mature cystic teratoma of the ovary. Attenuation of heart rate control and neural degeneration in nucleus ambiguus following chronic intermittent hypoxia in young adult Fischer 344 rats.

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SAVE: a grading protocol for clinically significant diabetic macular oedema based on optical coherence tomography and fluorescein angiography. Mood disorders are common, chronic, recurrent mental illnesses that affect the lives of millions of individuals worldwide. This behaviour suggests the lack of appreciable solvent dipolar relaxation in 5HI, which is consistent with our low temperature (77 K) emission data.

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Genetic polymorphisms of CAT (rs769218, rs769217), SOD2 (rs4880, rs2758331, rs5746136) and MPO (rs2071409, rs7208693) were determined. Tc-99m MIBI scintigraphy in multiple myeloma: prognostic value of different Tc-99m MIBI uptake patterns. Nonlinear dynamics and bifurcations of a coupled oscillator model for calling behavior of Japanese tree frogs (Hyla japonica). Groupings were partially congruent with the morphological taxonomy. Grossly, the liver was markedly enlarged with multifocal, well-circumscribed, pinpoint to 2 cm diameter pale tan nodular masses.

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An optical technique to characterize the accretion of material by microparticles is described. Use of cell culture of amnionic fluid for prenatal diagnosis of Tay-Sachs disease is described. tularensis immunogen to the nasal-associated lymphoid tissue in the presence of monoclonal Ab, which is FcRn-dependent.

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A search for linkage between the Ag and (dimeric) superoxide dismutase (SOD-1) loci. However, cerebral thrombosis has been reported in various vascular compartments following its use. A numerical example of the survival expected for an exponentially growing population of Chinese hamster V79 cells is presented.

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